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Research Assistant in Genome Engineering of Mouse Embryonic Stem Cells - Group Giorgetti - Job Opportunity at Friedrich Miescher Institute for Biomedical Research

Basel, Switzerland
Full-time
Mid-level
Posted: June 23, 2025
On-site
CHF 65,000 - 75,000 annually, reflecting Swiss research assistant standards for specialized genome engineering roles, with the high cost of living in Basel offset by excellent research infrastructure access and career development opportunities

Benefits

Two-year initial contract with extension possibilities providing job security and career development opportunities in a competitive research market
Access to cutting-edge scientific workshops and specialized training programs that enhance professional development and maintain technical competency
Collaborative team environment fostering knowledge sharing and professional networking within the international scientific community
Dynamic multicultural workplace exposure providing global perspective and cross-cultural communication skills valuable in international research careers
Affiliation with world-class biomedical research institute offering prestige and credibility for future career advancement
Access to state-of-the-art genome editing facilities and technologies typically unavailable in smaller research settings

Key Responsibilities

Engineer and optimize genetically modified mouse embryonic stem cell lines using advanced CRISPR/Cas9, transposon, and site-specific recombinase technologies to support groundbreaking genome regulation research
Execute sophisticated molecular biology experiments that directly contribute to understanding three-dimensional genome folding mechanisms and their impact on gene expression control
Maintain and culture specialized embryonic stem cell lines with precision and consistency to ensure research continuity and data reliability for high-impact publications
Collaborate strategically with graduate students, postdocs, and external research partners to advance multidisciplinary projects combining genome engineering, molecular biology, imaging, and computational modeling
Support current and future laboratory projects by providing technical expertise in genome engineering methodologies that advance the field of chromatin biology and gene regulation

Requirements

Education

Master's degree or equivalent experience in biology, biotechnology, or related field

Experience

Experience with mammalian tissue culture, standard molecular biology techniques, and genome engineering technologies

Required Skills

mammalian tissue culture standard molecular biology techniques genome engineering technologies CRISPR/Cas9 transposons site-specific recombinases excellent organization and planning skills clear and effective English communication collaborative work in multicultural teams
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Sauge AI Market Intelligence

Industry Trends

The genome engineering field is experiencing unprecedented growth driven by CRISPR technology democratization and increasing therapeutic applications, creating strong demand for specialists with hands-on experience in mammalian cell engineering and stem cell biology Research institutions are increasingly investing in three-dimensional genome organization studies as the field recognizes the critical role of chromatin architecture in gene regulation, disease mechanisms, and therapeutic target identification The biomedical research sector in Switzerland and Europe is expanding rapidly, with significant funding increases for fundamental research in genome regulation and chromatin biology, creating competitive opportunities for skilled research professionals

Role Significance

Typically works within a research group of 8-12 members including graduate students, postdocs, and technical staff, with direct collaboration responsibilities across multiple concurrent projects
Mid-level research position with significant technical responsibility and independence, serving as a crucial link between senior researchers and graduate students while maintaining specialized expertise in genome engineering methodologies

Key Projects

Development of novel CRISPR-based genome editing strategies for studying enhancer-promoter interactions in three-dimensional chromatin context Creation of genetically modified mouse embryonic stem cell models for investigating chromatin architecture and gene expression regulation Technical support for multidisciplinary projects combining molecular biology, advanced imaging, and computational modeling approaches

Success Factors

Technical mastery of advanced genome engineering techniques combined with meticulous attention to detail in stem cell culture maintenance and experimental reproducibility Strong collaborative skills enabling effective knowledge transfer and project coordination across diverse research teams with varying technical backgrounds Adaptability to rapidly evolving genome editing technologies and willingness to continuously update technical skills through professional development opportunities Strategic thinking ability to anticipate experimental challenges and develop innovative solutions for complex genome engineering problems

Market Demand

High demand for genome engineering specialists reflects the critical shortage of technically skilled professionals who can bridge molecular biology expertise with cutting-edge CRISPR technologies and stem cell culture methodologies

Important Skills

Critical Skills

CRISPR/Cas9 genome editing expertise is absolutely essential as this technology forms the foundation of modern genome engineering approaches and is central to all major research projects in the laboratory Mammalian tissue culture proficiency represents a fundamental requirement since all experimental work depends on maintaining healthy, genetically modified stem cell lines with consistent characteristics Molecular biology technique mastery is crucial for experimental execution, data generation, and troubleshooting complex protocols in genome engineering applications

Beneficial Skills

Advanced imaging techniques knowledge would enhance career prospects as the field increasingly integrates live-cell imaging with genome engineering approaches Computational biology skills are becoming increasingly valuable as genome engineering generates large datasets requiring bioinformatics analysis and interpretation Project management experience would facilitate career advancement into leadership roles within research teams and collaborative projects

Unique Aspects

Opportunity to work at the forefront of three-dimensional genome organization research, a rapidly advancing field with significant implications for understanding gene regulation mechanisms
Access to state-of-the-art genome engineering technologies and specialized equipment typically available only at world-class research institutions
Direct collaboration with internationally recognized experts in chromatin biology and genome regulation, providing exceptional mentorship and professional development opportunities
Location in Basel's vibrant life sciences ecosystem offering unparalleled access to industry connections, research collaborations, and career advancement opportunities

Career Growth

Career advancement typically occurs within 2-4 years, with opportunities for increased responsibility and specialization based on technical expertise development and research contributions

Potential Next Roles

Senior Research Specialist positions with increased project leadership responsibilities and technical team management PhD program enrollment leveraging hands-on genome engineering experience for advanced research degrees Industry transition to biotechnology companies focusing on therapeutic genome editing applications Research and development roles in pharmaceutical companies developing chromatin-targeted therapeutics

Company Overview

Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research represents one of Europe's premier fundamental research institutions, affiliated with University of Basel and Novartis, maintaining international recognition for excellence in genome regulation, multicellular systems, and neurobiology research

Top-tier research institute with strong competitive position in attracting international talent and securing major research funding, consistently producing high-impact scientific publications and maintaining strategic industry partnerships
Basel serves as Europe's leading life sciences hub, providing exceptional networking opportunities, industry connections, and access to the broader Swiss and European biomedical research ecosystem
International, collaborative environment emphasizing scientific excellence, diversity, and inclusion, with strong support for professional development and career advancement within the global research community
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