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Scientist, Early Chemical Development (12 Months Fixed Term Contract) - Job Opportunity at AstraZeneca

Macclesfield, United Kingdom
Contract
Mid-level
Posted: January 20, 2025
On-site
GBP 35,000 - 45,000 per year based on location and experience level

Benefits

Pharmaceutical industry exposure with leading global company
Research and development environment fostering innovation
Access to cutting-edge laboratory facilities
Professional development opportunities in drug development
Collaboration with cross-functional teams

Key Responsibilities

Design and implement new chemical processes for pharmaceutical ingredient production
Manage multi-kilogram API production meeting early phase timelines
Develop drug substance routes for clinical trials
Conduct data analysis and reporting of experimental results
Oversee batch manufacturing for discovery and pre-clinical use

Requirements

Education

Bachelor's degree or Master degree (BSc/MSc/MChem) in organic synthetic chemistry

Required Skills

Good understanding of synthetic reagents and methodologies Knowledge of reaction mechanisms Proficiency in modern analytical techniques (NMR and Mass Spectrometry) Experience in practical synthesis Good proficiency in retrosynthesis Good communication skills
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Sauge AI Market Intelligence

Industry Trends

Increased focus on process chemistry optimization for cost-effective drug manufacturing Growing demand for expertise in sustainable chemistry practices Rising importance of analytical method development in early-stage drug development Shift towards integrated drug development approaches combining chemistry and biology

Role Significance

Typically part of a 5-10 person process chemistry team within larger R&D organization
Mid-level position with significant technical responsibility but limited managerial duties

Key Projects

Early-stage API process development Scale-up optimization studies Clinical trial material preparation Analytical method development support

Success Factors

Strong foundation in organic synthesis and process chemistry Ability to work effectively in cross-functional teams Excellence in documentation and data analysis Understanding of GMP requirements for early phase development Adaptability to changing project priorities

Market Demand

High demand due to expanding pharmaceutical research sector and increasing focus on process optimization in early development stages

Important Skills

Critical Skills

Synthetic organic chemistry expertise is fundamental for process development and optimization Analytical technique knowledge essential for quality control and process validation Project management capabilities crucial for meeting development timelines

Beneficial Skills

Understanding of regulatory requirements for pharmaceutical manufacturing Experience with scale-up chemistry Knowledge of sustainable chemistry practices

Unique Aspects

Fixed-term contract offering valuable experience in early-stage drug development
Exposure to complete drug development process from discovery to clinical trials
Access to advanced analytical and manufacturing facilities

Career Growth

2-4 years typical progression to senior scientist role with demonstrated expertise

Potential Next Roles

Senior Scientist Principal Scientist Process Chemistry Team Leader Technical Project Manager

Company Overview

AstraZeneca

AstraZeneca is a global, science-led biopharmaceutical company focusing on discovery, development, and commercialization of prescription medicines

One of the world's largest pharmaceutical companies with strong presence in oncology, cardiovascular, and respiratory medicine
Major R&D hub in Macclesfield with significant investment in UK operations
Innovation-driven environment with emphasis on scientific excellence and cross-functional collaboration
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