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Sr. Research Investigator, Structural Biology - Job Opportunity at Incyte Corporation

Wilmington, USA
Full-time
Senior
Posted: April 27, 2025
On-site
USD 140,000 - 180,000 per year, based on location and experience level in biotech sector

Benefits

Leading-edge research facilities and state-of-the-art laboratory equipment
Opportunity to work on novel drug discovery projects
Career development in biotechnology sector
Collaborative research environment

Key Responsibilities

Lead gene-to-structure experimental workflows with focus on crystallization and structure determination
Design and manage protein expression strategies
Develop and optimize protein purification protocols using advanced chromatography techniques
Conduct comprehensive biophysical characterization of protein samples
Manage state-of-the-art crystallography laboratory operations
Supervise and mentor scientific team members
Drive integration of AI and structural biology approaches

Requirements

Education

Ph.D. in chemistry, structural biology, biochemistry or related field

Experience

5 years with Ph.D. or 10 years with BS/MS in biotech/pharma

Required Skills

Crystallography expertise Protein purification and characterization Biophysical characterization techniques Laboratory management Team leadership Communication skills Project management
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Sauge AI Market Intelligence

Industry Trends

Increasing integration of AI and machine learning in structural biology is revolutionizing drug discovery processes Growing demand for expertise in both traditional crystallography and emerging cryo-EM techniques reflects industry's hybrid approach to structure determination Rising importance of protein engineering and computational approaches in modern drug development indicates a shift toward more sophisticated structure-based drug design

Role Significance

Likely leading a team of 3-7 scientists and technicians, based on typical biotech research group structures
Senior leadership position with significant influence on drug discovery pipeline and technical direction

Key Projects

Novel drug target structural characterization Structure-based drug design programs Platform technology development for protein engineering Cross-functional collaboration with medicinal chemistry and biology teams

Success Factors

Strong technical expertise combined with strategic thinking and innovation capability Ability to bridge traditional structural biology with emerging computational methods Excellence in team leadership and cross-functional collaboration Track record of solving complex structural biology challenges in drug discovery context

Market Demand

High demand with growing importance due to increasing focus on structure-based drug design and the expansion of biologics development programs

Important Skills

Critical Skills

Advanced crystallography expertise essential for driving structure-based drug design Protein engineering capabilities crucial for optimizing target proteins Leadership skills vital for managing technical teams and collaborations

Beneficial Skills

Cryo-EM experience valuable for expanding structural biology capabilities Computational biology skills important for leveraging AI/ML approaches Experience with membrane proteins advantageous for challenging drug targets

Unique Aspects

Integration of AI with traditional structural biology methods sets this role apart from conventional positions
Opportunity to influence both small molecule and biologics drug discovery programs
Combination of hands-on research leadership with strategic program direction

Career Growth

3-5 years typically required for advancement to director level, depending on project success and organizational growth

Potential Next Roles

Director of Structural Biology Senior Director of Drug Discovery Head of Protein Sciences Chief Scientific Officer

Company Overview

Incyte Corporation

Incyte is a well-established biopharmaceutical company focused on innovative drug development in oncology and immunology

Mid-to-large cap biopharmaceutical company with strong market presence in specialty pharmaceutical sector
Significant presence in Delaware biotech corridor with global research operations
Research-driven environment emphasizing scientific excellence and innovation with collaborative approach to drug discovery
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